Manchester United suffered their third defeat in a week as late goals from Juan Zuniga and Troy Deeney gave Watford a deserved Premier League win.
The hosts led when Etienne Capoue converted Daryl Janmaat’s cut-back, only for Marcus Rashford to level from close range.
Zuniga powered in with seven minutes to go, 53 seconds after coming on.
And Deeney then scored a penalty in injury time after Marouane Fellaini fouled Zuniga in the box.
Following a derby defeat by Manchester City last weekend and the midweek Europa League loss to Feyenoord, Mourinho and United have had a rough eight days.
It is the first time Mourinho has lost three consecutive games in a season since February 2002, when he was Porto boss.
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